AG Mougiakakos

Medicine 5

Head of Department:
Prof. Dr. med. Andreas Mackensen

Laboratory for translational tumor- and transplantation immunology

A German Cancer Aid Max-Eder Junior Research Group

AG Mougiakakos

Research group: left: PD Dr. Dimitrios Mougiakakos (Leiter), Romy Loschinski (PhD Doktorand), Simon Jitschin (MTA), Dr. Dr. Regina Jitschin (Ärztin), Dr. Mirijeta Qorraj (Ärztin), Lisa Weigand (PhD Doktorand), Martina Braun (PhD Doktorand), Domenica Saul (MTA), Martin Böttcher (Postdoc)

not in the picture: Kristin Mentz (MTA), Jana Berger (MTA), Robert Gloger (Med. Doktorand)

 

 

Research Focus:


Our young research group is mainly interested in studying the alterations of the immune system due to cancer and after stem cell transplantation. A better knowledge regarding the tumor-associated strategies contributing to an immunosuppression will support the development of novel therapeutic strategies. Furthermore, we aim to “learn” from tumors how they specifically weaken immune responses in order to translate these findings into potential experimental approaches for the treatment of rejection reactions (so-called Graft-versus-Host disease) following stem cell transplantation.

 

Our research studies include:
• Metabolism and immune regulation
• Myeloid suppressor cells

• Mesenchymal stem cell
• Tumor metabolism 

Collaborations

internal
PD Dr. M. Büttner, Pathologisches Institut
PD Dr. A. Gießl, Department Biologie
Prof. Dr. M. Metzler, Pädiatrische Onkologie und Hämatologie
Dr. Prof. Dr. R. Maas, Institut für Pharmakologie und Toxikologie
Professor Dr. A. Steinkasserer, Abteilung Immunmodulation
PD Dr. C. Warnecke, Medizinische Klinik 4 für Nephrologie und Hypertensiologie
PD Dr. D. Mielenz, Abteilung für Molekulare Immunologie 

external 
Dr. L. Davies, Cardiff University
Dr. M. Eckart, Internistische Schwerpunktpraxis Erlangen
Dr. M. Herling, Klinik I für Innere Medizin, Uniklinik Köln
Prof. Dr. R. Kiessling, Karolinska Institut Stockholm
Prof. Dr. K. Le Blanc, Karolinska Institut Stockholm
Prof. Dr. T. Zenz, DKFZ, Heidelberg
Prof. Dr. B. Seliger, Institut für Medizinische Immunologie, Halle

Selected publications

Jitschin R, Braun M, Qorraj M, Saul D, Le Blanc K, Zenz T, Mougiakakos D.
Stromal cell-mediated glycolytic switch in CLL-cells involves Notch-c-Myc signaling.
Blood 2015, on-line prepublication

Jitschin R, Braun M, Büttner M, Bricks J, Berger J, Eckart MJ, Krause SW, Le Blanc K, Mackensen A, Mougiakakos D.
CLL-cells induce IDOhi CD14+HLA-DRlo myeloid derived suppressor cells that inhibit T-cell responses and promote TRegs.
Blood 2014;124(5):750-60.

Jitschin R, Hofmann AD, Bruns H, Gießl A, Bricks J, Berger J, Saul D, Eckart MJ, Mackensen A, Mougiakakos D.
Mitochondrial metabolism contributes to oxidative stress and reveals therapeutic targets in chronic lymphocytic leukemia.
Blood 2014;123(17):2663-72.

Mougiakakos D, Jitschin R, von Bahr L, Poschke I, Gary R, Sundberg B, Gerbitz A, Ljungman P, Le Blanc K.
Immunosuppressive CD14+HLA-DRlow/neg IDO+ myeloid cells in patients following allogeneic HSCT.
Leukemia 2013;27(2):377-88.

Le Blanc K and Mougiakakos D.
Multipotent Mesenchymal Stromal Cells and the Innate Immune System.
Nature Reviews Immunology 2012;12:383-96.

Publication  Medizin 5 

 
Contact
PD Dr. med. Dimitrios Mougiakakos
e-mail: dimitrios.mougiakakos@uk-erlangen.de
business card
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