RG Translational T cell Immunology (Reimann)
- tumor infiltrating lymphocytes
- (neo)epitope identification
- antigen processing and presentation
Lab members
- Dr. Hannah Reimann, Principle Investigator
- Katharina Korn, PhD Studentin
- Vanessa Lang, MTA
- Katharina Götz, MTA
- Tabea Koch, MD Student
Research focus
In our research group, we mainly focus on T-cell based immunotherapy of malignant diseases. In this context we analyze the intracellular processing of MHC class II restricted antigens, explore possible regulatory mechanisms of indirect antigen presentation and the effect of cell-specific processing of MHC class II antigens on the outcome of allogeneic stem cell transplantation. Differential processing of these antigens may enhance the graft-versus-leukemia effect without concomitant enhancement of graft-versus-host disease. Furthermore, we analyze the impact of antigen processing not only on allo-reactivity, but also on autoimmunity. Another core area of interest in our group is the identification of neoantigens in various solid tumors.
In a very recent project, we are analyzing the T cell response in the context of SARS-CoV-2 infection or vaccination.
Collaborations intern
- Prof. Dr. Peter Fasching, Frauenklinik, Erlangen
- Prof. Dr. Kai Hildner, Medizinische Klinik 1, Erlangen
- Prof. Dr. Thomas Winkler, Genetik, Erlangen
- Dr. Michael Aigner, Medizinische Klinik 5, Erlangen
- PD Dr. Simon Völkl, Medizinische Klinik 5, Erlangen
- Prof. Dr. Maike Büttner-Herold, Nephropathologie, Erlangen
- Dr. Gloria Lutzny-Geier, Medizinische Klinik 5, Erlangen
Collaborations extern
- Prof. Dr. Simone Thomas, Innere Medizin III, Regensburg
- Dr. Marieke Griffioen, Leiden University Medical Center, Leiden, The Netheralnds
- Prof. Tatyana Golovkina, Ph.D., The University Of Chicago, Chicago, USA
- Dr. Olivier Lantz, Institut Curie, Paris, France
Research support
- Bayerische Forschungsförderung
- Deutsche Forschungsgemeinschaft (DFG)
- ELAN, IZKF Erlangen
- Bayerisches Zentrum für Krebsforschung
Selected publications
Reimann, H., C. Moosmann, K. Schober, V. Lang, J. Verhagen, J. Zeun, A. Mackensen, A. N. Kremer, S. Völkl, and M. Aigner. “Identification and Characterization of T-cell receptors with therapeutic specificity against all SARS-CoV 2 strains.” Immunobiology, (Aug 2023). https://doi.org/10.1016/j.imbio.2023.152720.
Bergmann, C., F. Müller, J. H. W. Distler, A. H. Gyorfi, S. Völkl, M. Aigner, S. Kretschmann, H. Reimann, T. Harrer, N. Bayerl, S. Boeltz, A. Wirsching, J. Taubmann, W. Rosler, B. Spriewald, J. Wacker, A. Atzinger, M. Uder, T. Kuwert, A. Mackensen, and G. Schett. "Treatment of a Patient with Severe Systemic Sclerosis (Ssc) Using Cd19-Targeted Car T Cells." Ann Rheum Dis 82, no. 8 (Aug 2023): 1117-20. https://dx.doi.org/10.1136/ard-2023-223952.
Reimann, H., A. N. Kremer, V. Blumenberg, K. Schmidt, M. Aigner, B. Jacobs, N. Eisenhauer, A. Kampf, W. Rosler, S. Kharboutli, D. Mougiakakos, V. Lang, C. Lischer, P. Irrgang, M. Leppkes, J. V. Gonzalez, G. Kronke, A. E. Kremer, M. Tenbusch, H. Bruns, T. Harrer, F. Muller, G. Schett, A. Mackensen, M. Subklewe, and S. Völkl. "Cellular and Humoral Immune Responses to Sars-Cov-2 Vaccination in Patients after Cd19.Car T-Cell Therapy." Blood Adv 7, no. 10 (May 23 2023): 2066-69. https://dx.doi.org/10.1182/bloodadvances.2022007806.
Müller, F., S. Boeltz, J. Knitza, M. Aigner, S. Völkl, S. Kharboutli, H. Reimann, J. Taubmann, S. Kretschmann, W. Rosler, B. Manger, J. Wacker, D. Mougiakakos, S. Jabari, R. Schroder, M. Uder, F. Roemer, G. Kronke, A. Mackensen, and G. Schett. "Cd19-Targeted Car T Cells in Refractory Antisynthetase Syndrome." Lancet 401, no. 10379 (Mar 11 2023): 815-18. https://dx.doi.org/10.1016/S0140-6736(23)00023-5.
Kretschmann, S., S. Völkl, H. Reimann, G. Kronke, G. Schett, S. Achenbach, G. Lutzny-Geier, F. Müller, D. Mougiakakos, J. Dingfelder, C. Flamann, L. Hanssens, R. Gary, A. Mackensen, and M. Aigner. "Successful Generation of Cd19 Chimeric Antigen Receptor T Cells from Patients with Advanced Systemic Lupus Erythematosus." Transplant Cell Ther 29, no. 1 (Jan 2023): 27-33. https://dx.doi.org/10.1016/j.jtct.2022.10.004.
Mackensen, A., F. Müller, D. Mougiakakos, S. Boltz, A. Wilhelm, M. Aigner, S. Völkl, D. Simon, A. Kleyer, L. Munoz, S. Kretschmann, S. Kharboutli, R. Gary, H. Reimann, W. Rosler, S. Uderhardt, H. Bang, M. Herrmann, A. B. Ekici, C. Buettner, K. M. Habenicht, T. H. Winkler, G. Kronke, and G. Schett. "Anti-Cd19 Car T Cell Therapy for Refractory Systemic Lupus Erythematosus." Nat Med 28, no. 10 (Oct 2022): 2124-32. https://dx.doi.org/10.1038/s41591-022-02017-5.
Kremer, A. E., A. N. Kremer, C. Willam, S. Völkl, J. Verhagen, S. Achenbach, E. D. van der Meijden, V. Lang, M. Aigner, C. Maier, M. Tenbusch, K. Korn, G. Lutzny-Geier, S. Spoerl, R. Strauss, M. Vetter, K. Uberla, M. F. Neurath, A. Mackensen, M. Schiffer, and H. Hackstein. "Successful Treatment of Covid-19 Infection with Convalescent Plasma in B-Cell-Depleted Patients May Promote Cellular Immunity." Eur J Immunol 51, no. 10 (Oct 2021): 2478-84. https://dx.doi.org/10.1002/eji.202149277.
Verhagen, J., E. D. van der Meijden, V. Lang, A. E. Kremer, S. Völkl, A. Mackensen, M. Aigner, and A. N. Kremer. "Human Cd4(+) T Cells Specific for Dominant Epitopes of Sars-Cov-2 Spike and Nucleocapsid Proteins with Therapeutic Potential." Clin Exp Immunol 205, no. 3 (Sep 2021): 363-78. https://dx.doi.org/10.1111/cei.13627.
Bernhardt, A. L., J. Zeun, M. Marecek, H. Reimann, S. Kretschmann, J. Bausenwein, E. D. van der Meijden, M. M. Karg, T. Haug, L. Meintker, G. Lutzny-Geier, A. Mackensen, and A. N. Kremer. "Influence of Dm-Sensitivity on Immunogenicity of Mhc Class Ii Restricted Antigens." J Immunother Cancer 9, no. 7 (Jul 2021). dx.doi.org/10.1136/jitc-2021-002401.
Reimann, H., A. Nguyen, J. Z. Sanborn, C. J. Vaske, S. C. Benz, K. Niazi, S. Rabizadeh, P. Spilman, A. Mackensen, M. Ruebner, A. Hein, M. W. Beckmann, E. D. van der Meijden, J. Bausenwein, S. Kretschmann, M. Griffioen, J. Schlom, J. L. Gulley, K. L. Lee, D. H. Hamilton, P. Soon-Shiong, P. A. Fasching, and A. N. Kremer. "Identification and Validation of Expressed Hla-Binding Breast Cancer Neoepitopes for Potential Use in Individualized Cancer Therapy." J Immunother Cancer 9, no. 6 (Jun 2021). dx.doi.org/10.1136/jitc-2021-002605.
Kremer, A. N., J. Bausenwein, E. Lurvink, A. E. Kremer, C. E. Rutten, C. A. M. van Bergen, S. Kretschmann, E. van der Meijden, M. W. Honders, D. Mazzeo, C. Watts, A. Mackensen, J. H. F. Falkenburg, and M. Griffioen. "Discovery and Differential Processing of Hla Class Ii-Restricted Minor Histocompatibility Antigen Lb-Pip4k2a-1s and Its Allelic Variant by Asparagine Endopeptidase." Front Immunol 11 (2020): 381. dx.doi.org/10.3389/fimmu.2020.00381.
Kretschmann, S., S. Herda, H. Bruns, J. Russ, E. D. van der Meijden, U. Schlotzer-Schrehardt, M. Griffioen, I. K. Na, A. Mackensen, and A. N. Kremer. "Chaperone Protein Hsc70 Regulates Intercellular Transfer of Y Chromosome Antigen Dby." J Clin Invest 129, no. 7 (Jun 17 2019): 2952-63. https://dx.doi.org/10.1172/JCI123105.
Müller F., Taubmann J., Bucci L., Wilhelm A., Bergmann C., Völkl S., Aigner M., Rothe T., Minopoulou I., Tur C., Knitza J., Kharboutli S., Kretschmann S., Vasova I., Spoerl S., Reimann H., Munoz L., Gerlach R., Schaefer S., Grieshaber-Bouyer R., Korganow A., Farge-Bancel D., Mougiakakos D., Bozec A., Winkler T., Kroenke G., Mackensen A. and G. Schett.“ CD19 CAR T-Cell Therapy in Autoimmune Disease - A Case Series with Follow-up. “ NEJM (Feb 2024). 2024;390:687-700. DOI: 10.1056/NEJMoa230891
